An efficient approach to the asymmetric total synthesis of (–)-anisodine
J Chang, W Xie, L Wang, N Ma, S Cheng…
Index: Chang, Junbiao; Xie, Weilin; Wang, Limin; Ma, Nianchun; Cheng, Senxiang; Xie, Jingxi European Journal of Medicinal Chemistry, 2006 , vol. 41, # 3 p. 397 - 400
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Citation Number: 9
Abstract
–Anisodine (l-6, 7-epoxy-3-tropyl-α-hydroxytropate), which was isolated from the medicinal plant Scopolia tanguticus Maxim, was the first efficiently prepared using 6-β-acetyltropine as the starting material via a key step of the Sharpless asymmetric dihydroxylation (AD). The intermediate compounds 10 and 11 showed promising cholinergic activity.
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