Chemistry and physics of lipids

Preparation of ω-functionalized eicosane-phosphate building blocks

I Jablonkai, P Oroszlan

Index: Jablonkai, Istvan; Oroszlan, Peter Chemistry and Physics of Lipids, 2005 , vol. 133, # 1 p. 103 - 112

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Citation Number: 6

Abstract

New 1, 20-substituted eicosanes carrying phosphate headgroups and readily derivatizable thiol, maleimido, and activated carboxylic ester moieties were prepared. The C20-backbone of these molecules was assembled by a halopolycarbon homologation from 1, 8- dichlorooctane and 1, 6-dibromohexane. 20-Mercapto-and 20-maleimido-icosylphosphates were synthesized via ω-bromo di-t-butyl protected icosylphosphate while 20- ...