Synthesis, in vitro and in vivo preliminary evaluation of anti-angiogenic properties of some pyrroloazaflavones

…, L Urbani, B Oselladore, D Guidolin, R Di Liddo…

Index: Ferlin, Maria Grazia; Conconi, Maria Teresa; Urbani, Luca; Oselladore, Barbara; Guidolin, Diego; Di Liddo, Rosa; Parnigotto, Pier Paolo Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 1 p. 448 - 457

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Citation Number: 8

Abstract

This work investigated the in vitro and in vivo anti-angiogenic activity of some pyrroloazaflavones, exactly 2-phenyl-1H-pyrrolo [2, 3-h] quinolin-4 (7H) ones, with vinblastine as reference compound. Growth inhibitory activity, migration, and capillary-like structures formation were determined in human umbilical vein endothelial cell cultures, and Matrigel plug assay was carried out to evaluate in vivo effects on angiogenesis. ...