Tetrahedron letters

Artemisinin tricyclic analogs: Role of a methyl group at C-5a

…, D Desmaële, J d'Angelo, C Riche, F Gay, L Cicéron

Index: Zouhiri, Fatima; Desmaele, Didier; D'Angelo, Jean; Riche, Claude; Gay, Frederick; Ciceron, Liliane Tetrahedron Letters, 1998 , vol. 39, # 19 p. 2969 - 2972

Full Text: HTML

Citation Number: 17

Abstract

New artemisinin tricyclic analogs, bearing a methyl group at C-5a were synthetized through ozonation of vinylsilanes. Presence of such a substituent was detrimental to the antimalarial activity of these trioxanes, thus reinforcing the hypothesis that tight hemin-trioxane complexes are involved in the activation phase of these compounds.