Synthesis of Natural??Product??Like Molecules with Over Eighty Distinct Scaffolds

…, C Cordier, S Warriner, A Nelson

Index: Morton, Daniel; Leach, Stuart; Cordier, Christopher; Warriner, Stuart; Nelson, Adam Angewandte Chemie - International Edition, 2009 , vol. 48, # 1 p. 104 - 109

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Citation Number: 170

Abstract

A key challenge in chemical biology is the design and synthesis of compound libraries spanning large tracts of biologically relevant chemical space.[1–3] Libraries with high molecular shape diversity, a prerequisite for broad biological activity,[2] are particularly valuable in phenotypic screens. Despite this, organic chemistry is dominated by a remarkably small number of molecular scaffolds: in a recent study [4] of known cyclic ...