A new anti-tubulin agent containing the benzo [b] thiophene ring system

…, KM Dingeman, VP Mocharla, GR Pettit, R Bai…

Index: Pinney, Kevin G.; Bounds, A. Dawn; Dingeman, Koren M.; Mocharla, Vani P.; Pettit, George R.; Bai, Ruoli; Hamel, Ernest Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 8 p. 1081 - 1086

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Citation Number: 110

Abstract

A new type of inhibitor of tubulin polymerization was discovered based on the 3-aroyl-2- arylbenzo [b] thiophene molecular skeleton. The lead compound in this series, 2-(4′- methoxyphenyl)-3-(3′, 4′, 5′-trimethoxybenzoyl)-6-methoxybenzo [b] thiophene1, inhibited tubulin polymerization, caused an increase in the mitotic index of CA46 Burkitt lymphoma cells, and inhibited the growth of several human cancer cell lines.