Stereoselective Synthesis of Tri??and Tetrasubstituted Alkenes by Iron??Catalyzed Carbometalation Ring??Opening Reactions of Cyclopropenes

Y Wang, EAF Fordyce, FY Chen…

Index: Wang, Yi; Fordyce, Euan A. F.; Chen, Fung Yan; Lam, Hon Wai Angewandte Chemie - International Edition, 2008 , vol. 47, # 38 p. 7350 - 7353

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Citation Number: 48

Abstract

Alkenes are one of the major classes of chemical building blocks for organic synthesis. Although numerous methods exist for the preparation of alkenes, the stereoselective synthesis of tri-and tetrasubstituted [1] alkenes can still pose a significant challenge. One method that has enjoyed considerable success in this respect is the carbometalation of alkynes.[1–5] In this approach, the key issue is regioselectivity, which usually originates ...