Synthesis and Hepatitis C Antiviral Activity of 1??Aminobenzyl??1H??indazole??3??carboxamide Analogues

JJ Shi, FH Ji, PL He, Y Yang, W Tang, JP Zuo…

Index: Shi, Jing-Jing; Ji, Fei-Hong; He, Pei-Lan; Yang, Ya-Xi; Tang, Wei; Zuo, Jian-Ping; Li, Yuan-Chao ChemMedChem, 2013 , vol. 8, # 5 p. 722 - 725

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Citation Number: 5

Abstract

Hepatitis C virus (HCV) is a small (+)-RNA virus classified in the genus Hepaciviru of the family Flaviviridae.[1] Nearly 3% of the global population (approximately 170million) have been infected with HCV, while 3–4million are newly infected each year. Untreated HCV infections can progress to liver fibrosis, steatosis, cirrhosis, and even hepatocellular carcinoma.[2] Since the discovery of the virus in 1989,[3] much effort has been made to ...