Journal of fluorine chemistry

Synthesis and reactions of 4-sulpho-2, 3, 5, 6,-tetrafluorobenzoic acid

HC Fielding, IM Shirley

Index: Fielding, H. C.; Shirley, I. M. Journal of Fluorine Chemistry, 1992 , vol. 59, # 1 p. 15 - 31

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Citation Number: 14

Abstract

Abstract 4-Sulpho-2, 3, 5, 6-tetrafluorobenzoic acid (I) has been synthesised from pentafluorobenzoic acid via the oxidation of 4-mercapto-tetrafluorobenzoic acid. Reaction of I with DMF/SOCl 2 gave 1, 4-ClC 6 F 4 COCl (IIA) which was converted to 1, 4-ClC 6 F 4 COF (IIB) by fluoride exchange. Reaction with methanol or aniline gave respectively the methyl ester 1, 4-ClC 6 F 4 CO 2 Me (IIIA) and anilide 1, 4-ClC 6 F 4 CONHPh (IIIB). ...