Antitumor agents 243. Syntheses and cytotoxicity of desmosdumotin C derivatives

K Nakagawa-Goto, JH Wu, KF Bastow, CC Wu…

Index: Nakagawa-Goto, Kyoko; Wu, Jiu-Hong; Bastow, Kenneth F.; Wu, Chin-Chung; Lee, Kuo-Hsiung Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 6 p. 2325 - 2330

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Citation Number: 14

Abstract

New analogs of desmosdumotin C (1), in which other aromatic rings replaced the terminal phenyl group and the A-ring was modified, were synthesized. Compounds 2–9, 13, and 16 were evaluated in vitro against human tumor cell replication. The 4-bromophenyl analog (2) showed potent cytotoxic activity in four different tumor cell lines.

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