Synthesis of 4??Aminoxanthones by an Uncatalyzed, Multicomponent Reaction

A Bornadiego, J Diaz, CF Marcos

Index: Bornadiego, Ana; Diaz, Jesus; Marcos, Carlos F. Advanced Synthesis and Catalysis, 2014 , vol. 356, # 4 p. 718 - 722

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Citation Number: 9

Abstract

Abstract: The synthesis of xanthones via a multicomponent reaction of isocyanides is described for the first time. In this one-pot process, a tandem [4+ 1] plus [4+ 2] cycloaddition leads to polysubstituted 4-aminoxanthones in excellent to quantitative yields at room temperature in a non-catalyzed reaction. Keywords: biological activity; CÀC bond formation; cycloaddition; Diels–Alder reaction; heterocycles; multicomponent reactions