Synthetic Communications®

Three-component synthesis of pyrimidine and pyrimidinone derivatives in the presence of high-surface-area MgO, a highly effective heterogeneous base catalyst

H Sheibani, M Seifi, A Bazgir

Index: Sheibani, Hassan; Seifi, Mohammad; Bazgir, Ayoob Synthetic Communications, 2009 , vol. 39, # 6 p. 1055 - 1064

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Citation Number: 33

Abstract

Abstract Magnesium oxide (MgO) effectively catalyzes the three-component reaction of aldehydes, amidine systems, and malononitrile or ethyl cyanoacetate to form 4-amino-5- pyrimidine carbonitrile and pyrimidinone derivatives, respectively. The salient features of this method include high conversions, short reaction times, cleaner reaction profiles, and the use of inexpensive and readily available catalyst.