Potential noncataleptic neuroleptic agents: Synthesis and pharmacology of 7-chloro-4-[4-(2-hydroxyethyl) piperazino]-4, 5-dihydrothieno [2, 3-b]-1-benzothiepin

Z Polívka, M Valchář, M Protiva

Index: Polivka; Valchar; Protiva Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 10 p. 2970 - 2976

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Citation Number: 4

Abstract

Abstract Heating of 2, 5-dichloroacetophenone with 2-thiophenethiol, potassium carbonate and copper gave 5-chloro-2-(2-thienylthio) acetophenone (V) which was subjected to the Willgerodt reaction with sulphur and morpholine. The product was a mixture of the thiomorpholide VI and oxothiomorpholide VII. After a partial separation the predominanting product VI was hydrolyzed without characterization with ethanolic potassium hydroxide to ...