First Vilsmeier-Haack synthesis of flavones using bis-(trichloromethyl) carbonate/dimethylformamide

WK Su, XY Zhu, ZH Li

Index: Su; Zhu; Li Organic Preparations and Procedures International, 2009 , vol. 41, # 1 p. 69 - 75

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Citation Number: 11

Abstract

Flavones are a class of naturally occurring compounds with various biological activities. 1–4 One of the most commonly used methods for the synthesis of flavones is the cyclodehydration of 1-(2-hydroxyphenyl)-3-aryl-1, 3-propanediones. Many of these procedures use strong acids such as H2SO4, 5-6 HCl, 7 HBr or HI, 8 catalysts such as NaHSO4/SiO2, 9 H3PMo12O40· nH2O/SiO2, 10 H3PW12O40· nH2O/SiO2, 10 non- ...