An economical and versatile synthesis of 5, 8-dialkoxy-2-acetyl-3, 4-dihydronaphthalenes: key precursors for the synthesis of chiral anthracyclines

…, GJ Collin, PS Gee, RN Warrener

Index: Russell, Richard A.; Collin, Geoffrey J.; Gee, Paul S.; Warrener, Ronald N. Journal of the Chemical Society, Chemical Communications, 1983 , # 18 p. 994 - 995

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Abstract

5, 8-Diacetoxy-2-acetyl-3, 4-dihydronaphthalene, prepared by a new route from the Diels– Alder adduct of buta-1, 3-diene and-benzoquinone, is selectively deacetylated (CsCO in tetrahydrofuran or KCO in dimethyl sulphoxide) to intermediates suitable for use in chiral anthracycline synthesis.