Heterocycles

Heterocyclic amide hydraphile synthetic cation transporters

W Wang, CR Yamnitz, GW Gokel

Index: Wang, Wei; Yamnitz, Carl R.; Gokel, George W. Heterocycles, 2007 , vol. 73, # C p. 825 - 839

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Citation Number: 10

Abstract

Abstract A family of hydraphile ionophores has been prepared in which various∼ CH 2 N∼ to∼ CON∼ replacements have been made to assess the effect on Na+ transport through phospholipid bilayers. When the central relay (see graphical abstract) was a third macrocycle, symmetrical carbonyl for methylene replacements enhanced activity, but the presence of four or six amide residues diminished transport. When a pair of amides was ...