Total synthesis of bongkrekic acid

EJ Corey, A Tramontano

Index: Corey, E. J.; Tramontano, Alfonso Journal of the American Chemical Society, 1984 , vol. 106, # 2 p. 462 - 463

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Citation Number: 60

Abstract

14 a toxin produced by the microorganism Pseudomonas cocovenenans, has a sufficiently high affinity for the translocator on the inside of this membrane to block effectively the export of ATP. Ib Reported herein is the first chemical synthesis of 1, a substance only difficultly available by fermentation, which serves as a useful biochemical reagent and which is of interest also from a structural and biosynthetic point of view.