A Multicomponent Coupling Reaction Induced by Insertion of Arynes into the C O Bond of Formamide

E Yoshioka, S Kohtani, H Miyabe

Index: Yoshioka, Eito; Kohtani, Shigeru; Miyabe, Hideto Angewandte Chemie - International Edition, 2011 , vol. 50, # 29 p. 6638 - 6642

Full Text: HTML

Citation Number: 77

Abstract

Aryne compounds are highly reactive intermediates that have been widely used in organic synthesis.[1, 2] In recent years, studies on aryne-based reactions have achieved some remarkable success, particularly in sequential reactions with a nucleophile and an electrophile for the preparation of complex ortho-disubstituted arene derivatives,[3–5] which are difficult to synthesize by other methods. Most importantly, these advances have shown ...