A study of chemical carcinogenesis. 59. Improved photochemical synthesis of 5-methylchrysene derivatives and its application to the preparation of 7, 8-dihydro-7, 8- …

S Amin, J Camanzo, K Huie…

Index: Amin, Shantu; Camanzo, Joseph; Huie, Keith; Hecht, Stephen S. Journal of Organic Chemistry, 1984 , vol. 49, # 2 p. 381 - 384

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Abstract

EPMethylchrysene, a potent polynuclear aromatic hydrocarbon carcinogen, is a useful compound for studies in carcinogenesis because it has two dissimilar bay regions, one of which contains a methyl group. The latter feature seems to be a key factor in ita high carcinogenic The most versatile synthesis of 5-methylchrysene and ita derivatives is photocyclization of the appropriate 24 1-naphthyl)-1-phenylpropene (eq 1). However, the ...