Design and synthesis of 2-phenylimidazo [1, 2-a] pyridines as a novel class of melatonin receptor ligands

S El Kazzouli, AG du Bellay, S Berteina-Raboin…

Index: El Kazzouli, Said; Griffon Du Bellay, Amaury; Berteina-Raboin, Sabine; Delagrange, Philippe; Caignard, Daniel-Henry; Guillaumet, Gerald European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 4252 - 4257

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Citation Number: 33

Abstract

A novel class of imidazo [1, 2-a] pyridines as melatonin receptor ligands is designed and synthesized. The affinities of 3-(6-methoxy-2-phenylimidazo [1, 2-a] pyridine-3-yl)-N-methyl- propionamide 8, N-[2-(6-methoxy-2-phenylimidazo [1, 2-a] pyridine-3-yl)-ethyl]-acetamide 13 and N-(1-hydroxy-3-(5-methoxy-2-phenyl-1H-indol-3-yl) propan-2-yl) acetamide 18 are evaluated for binding on melatonin receptors. Compound 8 present good selectivity for ...