Novel 9-oxo-thiazolo [5, 4-f] quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: synthesis …
…, A Testard, V Thiéry, O Lozach, M Blairvacq…
Index: Loge, Cedric; Testard, Alexandra; Thiery, Valerie; Lozach, Olivier; Blairvacq, Melina; Robert, Jean-Michel; Meijer, Laurent; Besson, Thierry European Journal of Medicinal Chemistry, 2008 , vol. 43, # 7 p. 1469 - 1477
Full Text: HTML
Citation Number: 36
Abstract
Continuous efforts in microwave-assisted synthesis and the structure–activity relationships'(SARs) studies of novel modified 9-oxo-thiazolo [5, 4-f] quinazoline-2- carbonitriles, allowed identification of new amidine and imidate derivatives as potent and dual CDK1/GSK-3 inhibitors. Combination of lead optimization and molecular modeling studies allowed identification of a dual CDK1/GSK-3 inhibitor (compound 13d) with ...
Related Articles:
Thiazolo [5, 4-f] quinazolin-9-ones, inhibitors of glycogen synthase kinase-3
[Testard, Alexandra; Loge, Cedric; Leger, Benoit; Robert, Jean-Michel; Lozach, Olivier; Blairvacq, Melina; Meijer, Laurent; Thiery, Valerie; Besson, Thierry Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3419 - 3423]