Synthesis of novel orthoalkylaminophenol derivatives as potent neuroprotective agents in vitro

R Larget, B Lockhart, B Pfeiffer, A Neudorffer…

Index: Larget, Ronan; Lockhart, Brian; Pfeiffer, Bruno; Neudorffer, Anne; Fleury, Maurice-Bernard; Largeron, Martine Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2929 - 2934

Full Text: HTML

Citation Number: 14

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of orthoalkylaminophenol derivatives was synthesized and tested in vitro with respect to their neuroprotective effect. Some of these compounds exhibited a potent antioxidant activity close to that of standard α-tocopherol. ... The synthesis and in vitro neuroprotective ...