Semi??Synthesis and Biological Evaluation of 1, 2, 3??Triazole??Based Podophyllotoxin Congeners as Potent Antitumor Agents Inducing Apoptosis in HepG2 Cells
…, R Zhang, J Tang, H Lai, J Wang, G Wang…
Index: Chen, Jinying; Ma, Liang; Zhang, Ronghong; Tang, Jie; Lai, Huijun; Wang, Jun; Wang, Guangcheng; Xu, Qinyuan; Chen, Tao; Peng, Fei; Qiu, Jingxiang; Liang, Xiaolin; Cao, Dong; Ran, Yan; Peng, Aihua; Wei, Yuquan; Chen, Lijuan Archiv der Pharmazie, 2012 , vol. 345, # 12 p. 945 - 956
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Citation Number: 3
Abstract
Abstract A series of 4β-[(4-substituted)-1, 2, 3-triazol-1-yl] podophyllotoxin congeners were synthesized by employing click chemistry and further evaluated for their antitumor activity by MTT assay. Among them, six congeners (10, 11, 12, 13, 22, and 24) exhibited approximately 100-fold more potent inhibitory activity against four tumor cell lines (HepG2, MKN-45, NCI- H1993, and B16) than etoposide as positive control. Docking studies on binding in the ...
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