Preparation of Ketones from α, α-Disubstituted Acetoacetic Esters

WB Renfrow, GB Walker

Index: Renfrow; Walker Journal of the American Chemical Society, 1948 , vol. 70, p. 3957

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Citation Number: 15

Abstract

The ketonic cleavage is favored by a low concentration of alkali,'but maximum yields of ketones vary widely with the nature of the groups R and R'. Esters in which both R and R'are methyl, ethyl or n-butyl groups give 60-84% yieldszJ of ketones, but we have found that when R was an n-butyl group and R'was either an i-butyl or s-butyl group the yields of ketones were very low (lOo/o) and yields of disubstituted acetates were high even when ...