Synthesis and absolute configuration of novel N, O-psiconucleosides using (R)-N-phenylpantolactam as a resolution agent

…, L Sánchez, F Boschi, M Comes-Franchini…

Index: Camps, Pelayo; Gomez, Tania; Munoz-Torrero, Diego; Rull, Jordi; Sanchez, Laura; Boschi, Francesca; Comes-Franchini, Mauro; Ricci, Alfredo; Calvet, Teresa; Font-Bardia, Merce; De Clercq, Erik; Naesens, Lieve Journal of Organic Chemistry, 2008 , vol. 73, # 17 p. 6657 - 6665

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Citation Number: 14

Abstract

A series of novel N, O-psiconucleosides has been prepared in both enantiomeric forms by resolution of an advanced racemic synthetic intermediate using (R)-N-phenylpantolactam as a chiral resolution agent. The absolute configuration of all of these compounds has been unequivocally established by chemical correlation with the novel (R)-or (S)-1-methyl-5- phenylpyrrolidine-2, 3-dione, prepared from the known (R)-and (S)-1-methyl-5- ...