Towards a biocompatible artificial lung: Covalent functionalization of poly (4-methylpent-1-ene)(TPX) with cRGD pentapeptide

…, A Haverich, A Kirschning, G Dräger

Index: Moeller, Lena; Hess, Christian; Palecek, Jiri; Su, Yi; Haverich, Axel; Kirschning, Andreas; Draeger, Gerald Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 270 - 277

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Citation Number: 3

Abstract

Abstract Covalent multistep coating of poly (methylpentene), the membrane material in lung ventilators, by using a copper-free “click” approach with a modified cyclic RGD peptide, leads to a highly biocompatible poly (methylpentene) surface. The resulting modified membrane preserves the required excellent gas-flow properties while being densely seeded with lung endothelial cells.

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