Journal of medicinal chemistry

Radioiodine-labeled N, N-dimethyl-N'-[2-hydroxy-3-alkyl-5-iodobenzyl]-1, 3-propanediamines for brain perfusion imaging

KM Tramposch, HF Kung, M Blau

Index: Tramposch, Kenneth M.; Kung, Hank F.; Blau, Monte Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 121 - 125

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Citation Number: 57

Abstract

Method. A solution of IC1 (24.3 g, 150 mmol) in 60 mL of glacial acetic acid was added dropwise to a stirred solution of the appropriate salicylaldehyde (2-6) in 60 mL of glacial acetic acid. After the addition was completed, the dark mixture was heated for 4 h and then stirred at room temperature overnight. The reaction mixture was poured into 500 mL of water, and the product was extracted with two portions of methylene chloride. The ...