All E??10, 20??methanoretinoylopsin, light??stable rhodopsin. Synthesis and spectroscopy of all E??10, 20??methano??and all??E??retinoyl fluoride and their reaction with …

…, M Groesbeek, LJP Van Amsterdam…

Index: Steen, R. van der; Groesbeek, M.; Amsterdam, L. J. P. van; Lugtenburg, J.; Oostrum, J. van; Grip, W. J. de Recueil des Travaux Chimiques des Pays-Bas, 1989 , vol. 108, # 1 p. 20 - 27

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Citation Number: 14

Abstract

Abstract In order to obtain a light-stable rhodopsin as a potential candidate for crystallization and structural X-ray analysis, we synthesized and characterized the novel all E-10, 20- methano-retinoyl fluoride (2). This retinal analogue has a locked 11-cis configuration, preventing the light-induced 11-cis [RIGHTWARDS ARROW] trans isomerization and binds to opsin by a stable peptide bond rather than a Schiff base. 2 reacted with (methylated) ...