Synthesis and SAR studies of a novel class of S1P 1 receptor antagonists

…, C Suzuki, Y Sakata, Y Takuwa, F Nara, S Satoh

Index: Nakamura, Tsuyoshi; Yonesu, Kiyoaki; Mizuno, Yumiko; Suzuki, Chie; Sakata, Yuki; Takuwa, Yoh; Nara, Futoshi; Satoh, Susumu Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 10 p. 3548 - 3564

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Citation Number: 10

Abstract

A series of Sodium 4-[(4-butoxyphenyl) thio]-2′-substituted-1, 1′-biphenyl-3-sulfonates were identified as functional sphingosine-1-phosphate (S1P) antagonists with selectivity for the S1P1 receptor subtype starting from chemical lead 2, which was found while screening our in-house compound library. We performed chemical modifications on each regional structure of compound 2, for example, on the three ring compartments, the benzyl ...