Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an α-helix

BP Orner, JT Ernst, AD Hamilton

Index: Orner; Ernst; Hamilton Journal of the American Chemical Society, 2001 , vol. 123, # 22 p. 5382 - 5383

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Citation Number: 299

Abstract

The design of synthetic structures that mimic large and noncontiguous regions of a protein surface remains an elusive goal. 1 There has been considerable success in the field of small peptidomimetics that reproduce features of short peptides in extended2 or β-turn conformations. 3 However, much less progress has been made in the search for proteomimetics or nonpeptide structures that mimic larger areas of the protein surface4 ...