Isoxazole-3-hydroxamic acid derivatives as peptide deformylase inhibitors and potential antibacterial agents

P Cali, L Nærum, S Mukhija, A Hjelmencrantz

Index: Cali, Patrizia; Naerum, Lars; Mukhija, Seema; Hjelmencrantz, Anders Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 5997 - 6000

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Citation Number: 79

Abstract

A series of isoxazole-3-hydroxamic acid derivatives has been identified as a new class of small, nonpeptidic inhibitors of peptide deformylase (PDF). The synthesis, enzyme inhibition and preliminary investigation of the binding mode of this potential antibacterial compounds are reported.