Journal of heterocyclic chemistry

Synthesis of thiazole??containing benzo??crown ethers

HS Kim, YK Koh, JH Choi

Index: Kim, Hong-Seok; Koh, Young Kook; Choi, Jun-Hyeak Journal of Heterocyclic Chemistry, 1998 , vol. 35, # 1 p. 177 - 181

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Citation Number: 10

Abstract

Abstract A series of benzo-crown ethers containing the thiazole subcyclic moity have been synthesized. Reaction of 1, 2-bis (thioamidomethyloxy) benzene 2 with ethyl bromopyruvate in ethanol provided 1, 2-bis (thiazolyl) benzene 4 (80%) along with thiazole 5 (14%). Reduction of 4 with lithium aluminum hydride followed by mesylationbromination gave 7. Similar treatment of 5 with lithium aluminum hydride followed by bromination resulted in ...