Highly efficient synthesis of (R)-and (S)-piperazic acids using proline-catalyzed asymmetric α-hydrazination

…, K Makino, Y Yoshitomi, O Hara, Y Hamada

Index: Henmi, Yoshiaki; Makino, Kazuishi; Yoshitomi, Yayoi; Hara, Osamu; Hamada, Yasumasa Tetrahedron Asymmetry, 2004 , vol. 15, # 21 p. 3477 - 3481

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Citation Number: 29

Abstract

Piperazic acids (R)- and (S)-1, cyclic α-hydrazino acids, are not only components of several naturally occurring cyclodepsipeptides [1] and [2] with remarkable biological activities, but also useful synthetic intermediates in the preparation of medicinally important compounds, such as enzyme inhibitors. 3 To construct polyoxypeptins and GE3, 4 cyclodepsipeptides containing piperazic acids, in the quantities required for biological evaluation, we needed to produce ...