Catalytic enantioselective decarboxylative protonation

…, T Nishimata, DC Behenna, BM Stoltz

Index: McFadden, Ryan M.; Stoltz, Brian M. Journal of the American Chemical Society, 2006 , vol. 128, # 24 p. 7738 - 7739

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Citation Number: 89

Abstract

We report a highly enantioselective, general catalytic system for the facile synthesis of tertiary stereocenters by protonation adjacent to cyclic ketones. The method relies on catalytic decarboxylative protonation of readily accessible racemic quaternary β-ketoesters. A range of substituted cycloalkanone compounds can be accessed through this process with high levels of enantioselectivity.