Studies on hypolipidemic agents. IV. Syntheses and biological activities of trans-and cis-2-(4-alkylcyclohexyl)-2-oxoethyl arenesulfonates.

…, T TERADA, Y MURANAKA, T HAMAKAWA…

Index: Ogawa; Terada; Muranaka; Hamakawa; Ohta; Okamoto; Fujii Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 8 p. 3276 - 3283

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Citation Number: 9

Abstract

trans-and cis-2-Diazo-1-(4-alkylcyclohexyl)-1-ethanones were reacted with arenesulfonic acids to afford the corresponding 2-(4-alkylcyclohexyl)-2-oxoethyl arenesulfonates. The esteraseinhibitory activity and hypolipidemic effect of the arenesulfonates were examined, and it was found that in most cases, the trans-isomers were more active than the corresponding cis-isomers. Stereoselective syntheses of several biologically potent trans- ...