Simple and clean synthesis of ketones from internal olefins using PdCl 2/N, N-dimethylacetamide catalyst system

T Mitsudome, S Yoshida, Y Tsubomoto, T Mizugaki…

Index: Mitsudome, Takato; Yoshida, Syuhei; Tsubomoto, Yamato; Mizugaki, Tomoo; Jitsukawa, Koichiro; Kaneda, Kiyotomi Tetrahedron Letters, 2013 , vol. 54, # 12 p. 1596 - 1598

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Citation Number: 9

Abstract

A simple catalytic system consisting of PdCl2 and N, N-dimethylacetamide enabled clean and selective synthesis of ketones from internal olefins using molecular oxygen. Various functionalized internal olefins were directly and regioselectively oxidized; C atoms of CC bonds far from substituted moieties were preferably oxidized.