Synthesis of analogues of acyclic nucleoside diphosphates containing a (phosphonomethyl) phosphanyl moiety and studies of their phosphorylation

P Doláková, M Dračínský, J Fanfrlík…

Index: Dolakova, Petra; Dracinsky, Martin; Fanfrlik, Jindrich; Holy, Antonin European Journal of Organic Chemistry, 2009 , # 7 p. 1082 - 1092

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Citation Number: 7

Abstract

Abstract Acyclic nucleoside diphosphonate derivatives of purines and pyrimidines were prepared by Mitsunobu reaction of suitably protected heterocyclic bases with alcohols containing the (phosphonomethyl) phosphanyl moiety. Furthermore, nonhydrolyzable acyclic analogues of dUDP were prepared as potential inhibitors of dUTPase. Their phosphorylation to analogues of dUTP, however, gave mixtures of linear and branched ...