Tetrahedron

Enzymatic hydrolyses of acetoxy-and phenethylbenzoates by Candida cylindracea lipase

A Cipiciani, F Fringuelli, AM Scappini

Index: Cipiciani, Antonio; Fringuelli, Francesco; Scappini, Anna Maria Tetrahedron, 1996 , vol. 52, # 29 p. 9869 - 9876

Full Text: HTML

Citation Number: 15

Abstract

The lipase from Candida cylindracea (CCL) deacetyles rapidly and selectively all three regioisomer methyl acetoxybenzoates. In the enzymatic hydrolyses of analogous aryl acetoxybenzoates, the difference of reactivity between the acetoxy and benzoyloxy functionalities is reduced and a methoxy group in meta position of the aryl group reverses the reactivity order making the compounds aspirin or aspirin-like prodrugs. The degree of ...