Synthesis of highly N-substituted indole library via conjugate additions of indoline and their synthetic tool potentials

H Kilic, S Bayindir, E Erdogan, N Saracoglu

Index: Kilic, Haydar; Bayindir, Sinan; Erdogan, Esra; Saracoglu, Nurullah Tetrahedron, 2012 , vol. 68, # 27-28 p. 5619 - 5630

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Citation Number: 9

Abstract

The indole (1) ring is of great interest and significance since this sub-unit is found in numerous natural alkaloids. 1, 2, 3, 4, 5, 6 and 7 Therefore, intensive efforts have been devoted to the development of efficient methods for the synthesis of functionalized indoles. While many methods for the functionalization of indole at C3 are well established, 8, 9, 10 and 11 there is still limited ease of access to C2 and N-functionalized indoles ( Fig. 1). Although N-functionalized indoles also represent ...