Benzanilides with spasmolytic activity: chemistry, pharmacology, and SAR

G Brunhofer, N Handler, K Leisser, CR Studenik…

Index: Brunhofer, Gerda; Handler, Norbert; Leisser, Klaus; Studenik, Christian R.; Erker, Thomas Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 11 p. 5974 - 5981

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Citation Number: 11

Abstract

The following study describes the synthesis of new benzanilide derivatives and their pharmacological investigation on smooth muscle preparations of guinea pigs. All compounds were synthesized in good yields and showed a spasmolytic activity without significant effect on vascular smooth muscles and heart muscle preparations. Moreover, further pharmacological investigations as well as in silico studies were performed to ...