Synthesis of perfragilin B, A cytotoxic isoquinoline quinone isolated from the bryozoan Membranipora perfragilis
A Park, FJ Schmitz
Index: Park, Aeri; Schmitz, Francis J. Tetrahedron Letters, 1993 , vol. 34, # 25 p. 3983 - 3984
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Citation Number: 11
Abstract
Abstract The cytotoxic isoquinoline quinone perfragilin B (2), which was isolated from the bryozoan Membranipora perfragilis, has been synthesized. The key step involves a Diels- Alder reaction between a substituted 2-azabutadiene (4) and 2, 3-bis (thiomethyl)-1, 4- benzoquinone (6) to produce the isoquinoline skeleton.
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