Proflavine derivatives as fluorescent imaging agents of amyloid deposits

…, M Dubois-Dauphin, FM Laferla, M Demeunynck…

Index: Garin, Dominique; Oukhatar, Fatima; Mahon, Andrew B.; Try, Andrew C.; Dubois-Dauphin, Michel; Laferla, Frank M.; Demeunynck, Martine; Sallanon, Marcelle Moulin; Chierici, Sabine Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2203 - 2206

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Citation Number: 6

Abstract

A series of proflavine derivatives for use to further image Aβ amyloid deposits were synthesized and characterized. Aged 3xTg-AD (23months old) mice hippocampus sections incubated with these derivatives revealed preferential labeling of amyloid plaques. Furthermore an in vitro binding study showed an inhibitory effect, although moderate, of these compounds on Aβ40 fibril formation. This study highlights the potential of proflavine ...