Metabolism of pentacarboxylate porphyrinogens by highly purified human coproporphyrinogen oxidase: Further evidence for the existence of an abnormal pathway for …
CL Cooper, CM Stob, MA Jones, TD Lash
Index: Cooper, Christopher L.; Stob, Christian M.; Jones, Marjorie A.; Lash, Timothy D. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 22 p. 6244 - 6251
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Citation Number: 10
Abstract
An abnormal series of porphyrin tetracarboxylic acids known as the isocoproporphyrins, are commonly excreted by patients suffering from the disease porphyria cutanea tarda (PCT). These porphyrins appear to arise by bacterial degradation of dehydroisocoproporphyrinogen that is generated by the premature metabolism of the normal pentacarboxylate intermediate (5dab) by coproporphyrinogen oxidase (copro'gen ...
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