Ligand exchange reaction of sulfoxides in organic synthesis: A new method for generation of magnesium enolates of α-chloro carboxylic acids and their derivatives
T Satoh, Y Kitoh, K Onda, K Yamakawa
Index: Satoh, Tsuyoshi; Kitoh, Yasushi; Onda, Ken-ichi; Yamakawa, Koji Tetrahedron Letters, 1993 , vol. 34, # 14 p. 2331 - 2334
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Citation Number: 12
Abstract
Abstract Treatment of α-chloro α-sulfinyl carboxylic acid derivatives with EtMgBr in THF at low temperature gave magnesium enolates of the α-chloro carboxylic acid derivatives. The enolates reacted with ketones and aldehydes to afford aldol compounds (or α, β-epoxy acids) in good yields.
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