Tetrahedron

Synthesis and conformational investigation of tetrapeptide analogues of the fragment B23-B26 of insulin

LM Rodrigues, JI Fonseca, HLS Maia

Index: Rodrigues, Ligia M.; Fonseca, Jose I.; Maia, Hernani L.S. Tetrahedron, 2004 , vol. 60, # 40 p. 8929 - 8936

Full Text: HTML

Citation Number: 11

Abstract

Tetrapeptides containing one of a set of four different α, α-dialkyl glycines at the C-terminus were synthesized by conventional methods in solution and their conformational behavior investigated by 1H NMR spectroscopy in connection with molecular mechanics calculations. The results were consistent with conformations stabilized by a γ-turn in the case of compounds with alkyl groups larger than methyl, while the corresponding Aib derivative ...