Discovery of novel 4-(2-fluorophenoxy) quinoline derivatives bearing 4-oxo-1, 4-dihydrocinnoline-3-carboxamide moiety as c-Met kinase inhibitors

…, Y Zhao, K Wang, Y Gao, J Han, B Cui, P Gong

Index: Li, Sai; Zhao, Yanfang; Wang, Kewen; Gao, Yali; Han, Jianming; Cui, Bingbing; Gong, Ping Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 11 p. 2843 - 2855

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Citation Number: 19

Abstract

A series of novel 4-(2-fluorophenoxy) quinoline derivatives containing 4-oxo-1, 4- dihydrocinnoline-3-carboxamide moiety were designed, synthesized and evaluated for their in vitro biological activities against c-Met kinase and six typical cancer cell lines (A549, H460, HT-29, MKN-45, U87MG and SMMC-7721). All the prepared compounds showed moderate to excellent antiproliferative activity, and the analysis of their structure–activity ...