Tetrahedron letters

First organophosphorus radical-mediated cyclisations to afford medium-sized rings: eight-membered lactones and seven-and eight-membered lactams

…, F Schönebeck, JA Murphy, AH Payne, AC Williams

Index: Lang, Stuart; Corr, Michael; Muir, Neil; Khan, Tanweer A.; Schoenebeck, Franziska; Murphy, John A.; Payne, Andrew H.; Williams, Andrew C. Tetrahedron Letters, 2005 , vol. 46, # 23 p. 4027 - 4030

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Citation Number: 31

Abstract

The phosphorus based radical precursors N-ethylpiperidine hypophosphite (EPHP) and diethylphosphine oxide (DEPO) are efficient reagents for carrying out the formation of seven- and eight-membered rings. Esters and amides were successfully converted into the corresponding eight-membered lactones and seven-and eight-membered lactams in good to excellent yields.