Synthesis, Pharmacological and Biophysical Characterization, and Membrane-Interaction QSAR Analysis of Cationic Amphiphilic Model Compounds⊥
…, C Schellinski, S Landmann, S Hauschild…
Index: Klein, Christian D. P.; Klingmueller, Martin; Schellinski, Christiane; Landmann, Silke; Hauschild, Stefanie; Heber, Dieter; Mohr, Klaus; Hopfinger Journal of Medicinal Chemistry, 1999 , vol. 42, # 19 p. 3874 - 3888
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Citation Number: 17
Abstract
Cationic amphiphilic drugs have a propensity to interact with biological interphases. This study was designed to gain more insight into the molecular properties of catamphiphilic drugs which govern this type of interaction. A series of phenylpropylamine model compounds were synthesized in which modifications were incorporated at the aromatic part of the molecule. The replacement of 45Ca2+ from phosphatidylserine monolayers served ...
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