Synthesis of azepino [4, 5-b] indolones via an intermolecular radical oxidative substitution of N-Boc tryptamine

PE Reyes-Gutiérrez, RO Torres-Ochoa…

Index: Reyes-Gutierrez, Paul E.; Torres-Ochoa, Ruben O.; Martinez, Robertoz; Miranda, Luis D. Organic and Biomolecular Chemistry, 2009 , vol. 7, # 7 p. 1388 - 1396

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Citation Number: 42

Abstract

The oxidative radical substitution of aromatic systems is an important carbon-carbon bond formation process that provides numerous possibilities to access diverse synthetically and pharmacologically important molecules. 10–12 Kerr and coworkers recently described the synthesis of the tetracyclic-azepinoindolone tronocarpine core (2) using a Mn(OAc) 3 -mediated radical oxidative cyclization of N-alkylated indole-3-acetonitrile. 2a An efficient approach to the ...