Synthesis,. beta.-adrenergic activity, and platelet antiaggregatory activity of a positional isomer of trimetoquinol: 1-(2', 4', 5'-trimethoxybenzyl)-6, 7-dihydroxy-1, 2, 3, 4- …

…, JF Bossart, JR Mayo, DR Feller

Index: Miller; Bossart; Mayo; Feller Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 331 - 333

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Citation Number: 5

Abstract

A positional isomer of trimetoquinol (l), 1-(2', 4', 5'-trimethoxybenzyl)-6, 7-dihydroxy-l, 2, 3, 4- tetrahydroisoquinoline (3), was synthesized and found to possess less &adrenergic activity than 1 in isolated guinea pig atrial and tracheal preparations. The analogue 3 was an effective antiaggregatory agent in human and rabbit platelet-rich plasma preparations, while 1 was effective only as an inhibitor of arachidonic acid induced aggregation in human ...